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Hair Growth Science

We have carefully designed The Hair Growth Kit to create the best environment for regenerating hair growth and stopping hair loss.

Numbers don’t lie

More than 80% of men experience significant hair loss during their lifetime and 1 in 4 will experience this before the age of 30.

A typical male scalp bears 100.000 to 150.000 hairs. Normally, between 50 and 100 of them fall out daily as they complete their growth cycle while new hairs keep growing. But when the shedding outpaces the growth, the result is hair loss. This occurs when follicles become overly sensitive to a hormone and deteriorate. As a result, the growth phase shortens until it finally stops.

Here you can read an in-depth description of the science behind The Hair Growth Kit and how it helps reversing topical hair loss.

Clinical Study

In a 150 day clinical study, The Hair Growth Kit proved to be efficient in activating new hair growth, as well as preventing further hair loss.

Here’s what the clinical study concluded:

96 % Activated new hairs
55 % Improved beard density
55 % Improves hair density
10 % Improved hair thickness

Moonroller

The Moonroller is made to stimulate hair growth by making the absorption of the Activator Hair Serum as effective as possible.

It consists of 1140 titanium needles that penetrate the top layer of the scalp and create thousands of microscopic channels. This process boosts the blood flow increasing the nutritional distribution to both inactive and active follicles.

Activator Serum

This is a serum proven to stimulate inactive follicles and prevent them from entering the hair loss phase.

The hair growth effect is found in our patented Triple Complex™, proven to target hair growth, thickness, and strength through multiple actives specifically designed to boost the energy cycles during the night, while the hair growth processes are most active in the scalp.

In the TripleComplex™ you’ll find three actives in a unique composition:

Capilia longa
Capilia longa™ represents the first generation of plant growth factors (Phyto-Peptidic Fractions™) and achieves hair growth reactivation by resetting the hair bulb, re-starting the activity of the dermal papilla cells (the bottom of the follicle), and creating the optimal micro-environment to activate hair growth.

Elaya Renova
Elaya Renova works at the biomolecular level with three objectives. When it gets delivered into the core of the hair strand, it reinforces the strand, hair thickness & volume, and significantly increases the hair diameter.

Centella Reversa
Centella Reversa works as a powerful antioxidant, speeding up the process of micro “wound healing” in the follicle and rebuilding the surrounding core skin structure in the tissue, resulting in rapid stimulation of cell detoxification.

The Hair Cycle

The hair cycle has 3 phases:

Anagen in which the hair grows actively.
Catagen in which the hair stops growing.
Telogen in which the hair falls off.

In the hair bulb, there is a mix of molecules regulated by the dermal papilla cells that change from phase to phase, and causes the transition from one phase to the next. When there is an imbalance in the cycle, hair loss accelerates, and the dermal papilla cells enter a latent, inactive state, stopping the processes of creation of new hairs and starting a new hair cycle.

CAPILIA LONGA™

The ingredient CAPILIA LONGA™ represents the first generation of plant growth factors (Phyto-Peptidic Fractions™) and achieves hair growth reactivation through a biological approach. The concentrated secretome of totipotent cells from Curcuma longa rhizome is rich in signalling peptides specially designed to create the optimal micro-environment to activate hair growth.

All of this helps produce an epigenetic reset of the hair bulb, re-starting the activity of the dermal papilla cells.

The dermal papilla is a structure made of specialized fibroblasts located in the base of the hair follicle - the hair bulb. It is one of the most rapidly proliferating tissues in the human body and is crucial for the re-activation and regulation of follicle development and growth.

Some essential functions of the dermal papilla:

Regulates the hair growth cycle.
Activates hairs - through proliferation and differentiation of keratinocytes in the hair matrix.
Determines the quality and size of produced hair.
Regenerates the whole follicle.

Under the correct microenvironment in the hair bulb, dermal papilla cells work correctly and regulate several key molecules, including growth factors, nutrients, and miRNAs.

The ingredient CAPILIA LONGA™ represents the first generation of plant growth factors (Phyto-Peptidic Fractions™) and achieves hair growth reactivation through a biological approach. The concentrated secretome of totipotent cells from Curcuma longa rhizome is rich in signalling peptides specially designed to create the optimal micro-environment to activate hair growth.

All of this helps produce an epigenetic reset of the hair bulb, re-starting the activity of the dermal papilla cells.

The dermal papilla is a structure made of specialized fibroblasts located in the base of the hair follicle - the hair bulb. It is one of the most rapidly proliferating tissues in the human body and is crucial for the re-activation and regulation of follicle development and growth.

Some essential functions of the dermal papilla:

Regulates the hair growth cycle.
Activates hairs - through proliferation and differentiation of keratinocytes in the hair matrix.
Determines the quality and size of produced hair.
Regenerates the whole follicle.

Under the correct microenvironment in the hair bulb, dermal papilla cells work correctly and regulate several key molecules, including growth factors, nutrients, and miRNAs.

+ Read more - Read less

How does Capilia Longa in The Activator work?

Capilia Longa is specially designed to create a beneficial microenvironment in the hair bulb in order to optimize the function of the dermal papilla cells. The correct microenvironment is achieved with two strategies:

Guiding strategy:
The strategy is achieved through the composition of the Phyto-Peptidic Fractions™ from Curcuma Longa stem cells rich in plant peptides, plant growth factors, transcription factors and epigenetic factors.

The guiding strategy is based on modulating which molecules are produced by the dermal papilla cells in order to regulate the growth cycles of the hair. Capilia Longa demonstrates the capability of promoting the generation of key molecules present in the growth phase and enlarge the duration of the growth phase while prolonging the transition to the hair loss phase.

Feeding strategy:
The Feeding strategy provides the optimal nutrients in the hair follicle to activate the dermal papilla proliferation. The activated proliferation of the dermal papilla combined with the guiding activity optimizes the hair growth cycle duration having direct consequences in the hair growth and reducing the hair loss.

In conclusion, through the use of these two strategies, Caplilia Longa is able to produce an epigenetic reset of the hair bulb, reactivating the activity of latent dermal papilla cells and promoting the hair follicle regeneration to activate new hairs.

Capilia Longa is specially designed to create a beneficial microenvironment in the hair bulb in order to optimize the function of the dermal papilla cells. The correct microenvironment is achieved with two strategies:

Guiding strategy:
The strategy is achieved through the composition of the Phyto-Peptidic Fractions™ from Curcuma Longa stem cells rich in plant peptides, plant growth factors, transcription factors and epigenetic factors.

The guiding strategy is based on modulating which molecules are produced by the dermal papilla cells in order to regulate the growth cycles of the hair. Capilia Longa demonstrates the capability of promoting the generation of key molecules present in the growth phase and enlarge the duration of the growth phase while prolonging the transition to the hair loss phase.

Feeding strategy:
The Feeding strategy provides the optimal nutrients in the hair follicle to activate the dermal papilla proliferation. The activated proliferation of the dermal papilla combined with the guiding activity optimizes the hair growth cycle duration having direct consequences in the hair growth and reducing the hair loss.

In conclusion, through the use of these two strategies, Caplilia Longa is able to produce an epigenetic reset of the hair bulb, reactivating the activity of latent dermal papilla cells and promoting the hair follicle regeneration to activate new hairs.

+ Read more - Read less

Key Markers

The following markers play a key role in the guiding strategy of Capilia longa and how it can modulate its expression is the base of its activity.

Insulin Growth Factor-1 (IGF-1)
Dermal papilla cells segregate molecules, including growth factors such as IGF-1, which stimulates the follicle development maintaining the Anagen phase and postponing the entrance into the Catagen phase. It is also essential for the growth and differentiation of follicles. CAPILIA LONGA increases its production of this factor in the dermal papilla.

miRNAs
In both plants, animals and humans, microRNAs (miRNAs) are key elements for the modulation of organism development, and in hair growth, their crucial role has just been recently discovered: they are involved in the control of each cycle phase and regulate the transition between phases when targeting different signaling pathways and transcription factors. About 200miRNAs are engaged in the different stages, but two are especially important for the hair follicle: miRNA-31 and miRNA-22.

miRNA-31 (miR-31) [8,9]
Its expression is intense and exclusive in the Anagen phase. It controls diverse signaling routes related to cell differentiation and hair formation. It promotes the follicle’s transition from the Telogen to Anagen phase, and if inhibited, the Catagen phase starts.
CAPILIA LONGA increases its expression.

miRNA-22 (miR-22) [10]
Involved in the premature transition to the regression of the hair follicle, its expression increases during the Catagen phase and it is the highest during the Telogen phase. Its induction is enough to promote the transition between the Catagen phase and its progression.
CAPILIA LONGA decreases its expression.

The following markers play a key role in the guiding strategy of Capilia longa and how it can modulate its expression is the base of its activity.

Insulin Growth Factor-1 (IGF-1)
Dermal papilla cells segregate molecules, including growth factors such as IGF-1, which stimulates the follicle development maintaining the Anagen phase and postponing the entrance into the Catagen phase. It is also essential for the growth and differentiation of follicles. CAPILIA LONGA increases its production of this factor in the dermal papilla.

miRNAs
In both plants, animals and humans, microRNAs (miRNAs) are key elements for the modulation of organism development, and in hair growth, their crucial role has just been recently discovered: they are involved in the control of each cycle phase and regulate the transition between phases when targeting different signaling pathways and transcription factors. About 200miRNAs are engaged in the different stages, but two are especially important for the hair follicle: miRNA-31 and miRNA-22.

miRNA-31 (miR-31) [8,9]
Its expression is intense and exclusive in the Anagen phase. It controls diverse signaling routes related to cell differentiation and hair formation. It promotes the follicle’s transition from the Telogen to Anagen phase, and if inhibited, the Catagen phase starts.
CAPILIA LONGA increases its expression.

miRNA-22 (miR-22) [10]
Involved in the premature transition to the regression of the hair follicle, its expression increases during the Catagen phase and it is the highest during the Telogen phase. Its induction is enough to promote the transition between the Catagen phase and its progression.
CAPILIA LONGA decreases its expression.

+ Read more - Read less
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